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Permalink : http://id.nii.ac.jp/1094/00000199/
Challenge in protein-small molecule Interactions
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| File / Name | License |
|---|---|
| 01-003-03-01- Challenge in protein-small・・・内山 |
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01-003-03-01- Challenge in protein-small・・・内山
(295.4KB)
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| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper |
|---|---|
| 言語 | 英語 |
| キーワード |
conformational change, torsion strain, protein-protein interaction, protein binding surface areas, tumor necrosis factor, TNFR |
| 著者 |
内山 文昭
/ ウチヤマ フミアキ
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| 抄録 |
(Abstract)
The potential for driving force in protein-ligand binding are discussed in this review. The conformational change in protein-ligand interaction is dependent on characteristics of proteins. Proteins which do not change conformation before ligand binding compose of constraint binding site residues. The conformation of ligand-binding sites of these proteins adopts disallowed Ramachandran angels. Conformational changes in protein-ligand binding result to adopt energetically unfavorable or disallowed Ramachandran angels. These findings show that an element of driving forces in protein-ligand binding may be the generation of torsion-angle strain. |
| 雑誌名 | 中村学園大学薬膳科学研究所研究紀要 |
| 号 | 3 |
| ページ | 1 - 6 |
| 発行年 | 2010-04-05 |
| 出版者 |
中村学園大学薬膳科学研究所
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| ISSN |
18829384
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