{"created":"2023-06-19T09:16:52.943923+00:00","id":240,"links":{},"metadata":{"_buckets":{"deposit":"c28918f3-4db5-4f05-8600-3947dcfc6f91"},"_deposit":{"created_by":17,"id":"240","owners":[17],"pid":{"revision_id":0,"type":"depid","value":"240"},"status":"published"},"_oai":{"id":"oai:nakamura-u.repo.nii.ac.jp:00000240","sets":["27","27:35"]},"author_link":["244"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"中村学園大学薬膳科学研究所研究紀要"},{"bibliographic_title":"Proceedings of PAMD Institute of Nakamura Gakuen University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(Abstract)\nThe potential for driving force in protein-ligand binding are discussed in this review. The conformational change in protein-ligand interaction is dependent on characteristics of proteins. Proteins which do not change conformation before ligand binding compose of constraint binding site residues. The conformation of ligand-binding sites of these proteins adopts disallowed Ramachandran angels. Conformational changes in protein-ligand binding result to adopt energetically unfavorable or disallowed Ramachandran angels. These findings show that an element of driving forces in protein-ligand binding may be the generation of torsion-angle strain.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"中村学園大学薬膳科学研究所"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18829384","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内山, 文昭"},{"creatorName":"ウチヤマ, フミアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"244","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-09-30"}],"displaytype":"detail","filename":"01-003-03-01- Challenge in protein-small・・・内山.pdf","filesize":[{"value":"295.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"01-003-03-01- Challenge in protein-small・・・内山","url":"https://nakamura-u.repo.nii.ac.jp/record/240/files/01-003-03-01- Challenge in protein-small・・・内山.pdf"},"version_id":"074fc231-d23a-421b-947e-599a5ee2087e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"conformational change","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"torsion strain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein-protein interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"protein binding surface areas","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tumor necrosis factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TNFR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Challenge in protein-small molecule Interactions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Challenge in protein-small molecule Interactions","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"17","path":["27","35"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-04-05"},"publish_date":"2010-04-05","publish_status":"0","recid":"240","relation_version_is_last":true,"title":["Challenge in protein-small molecule Interactions"],"weko_creator_id":"17","weko_shared_id":-1},"updated":"2023-06-19T09:32:36.859816+00:00"}