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スギ花粉症マウスモデルの作製とその評価
https://nakamura-u.repo.nii.ac.jp/records/267
https://nakamura-u.repo.nii.ac.jp/records/2673b44fd06-1524-4144-8c53-c98d68ba01ac
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
01-003-01-01- スギ花粉マ・・・内山、朱、大野他 (850.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-31 | |||||
| タイトル | ||||||
| タイトル | スギ花粉症マウスモデルの作製とその評価 | |||||
| タイトル | ||||||
| タイトル | Characterization of Cry j I-sensitized mice as a model of Japanese cedar pollenosis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | スギ花粉 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | スギ花粉症｜マウス｜花粉症｜マウスモデル | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cry j I-sensitized mice | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | Cry j I | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | IgE | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | IgG | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | mice | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 主題 | cedar pollen | |||||
| キーワード | ||||||
| 言語 | en | |||||
| 主題Scheme | Other | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 著者 |
内山, 文昭
× 内山, 文昭× 朱, 根勝× 大野, 阿由美× 千原, 智美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | (Abstract) Japanese cedar pollenosis is a type I allergic disease mediated by immunoglobulin E(IgE)antibodies.Here, we describe that a murine model of Japanese cedar pollenosis displays Th2 dominance in the pattern of immunoglobulin class. Intraperitoneal immunization of BALB/c mice with alum adjuvant Cry j I induced variable levels of Cry j I-specific IgE antibodies as well as increased total IgE antibodies. The production of Cry j I-specific IgE antibodies was increasing with repeat immunization. The balance of Th1/Th2 responses is investigated in Cry j I-sensitized mice. The production of Cry j I-specific IgE antibodies did not synchronized to produce igG2a antibodies but igG1 antibodies against Cry j I. These results show that Cry j I-sensitized BALB/c mice may be promoted to a shift in the Th1/Th2 balance toward TH2 dominance similar to human pollenosis. Gender influence on specific IgE level is tested in the murine model. Serum total IgE levels before immunization were higher in female (24.0ng/ml) than in male (12.6ng/ml) of BALB/c mice at the age of 8 weeks (p<0.0005). Serum total IgE levels in male (60.4ng/ml) and female (76.4ng/ml) Cry j I-immunized mice increased with direct propotion to the basal IgE levels with gender difference (p<0.05). Cry j I-specific IgE levels in serum were higher in female than in male (p<0.05). There is no significant difference in serum IgG1 levels between male and female mice with or without immunization. These results show that female BALB/c mice may be more sensitive to induce IgE antibodies than male. Oral intake of water soluble fraction of Astragali Radix at dose of 170μg/kg/day was tend to attenuate the production of Cry j I-specific igE antibodies in the murine model although not decreased the production of both total IgE and IgG antibodies. The present study indicates that Cry j I-sensitized BALB/c mice may be useful for analysis of Japanese cedar pollenosis in characteristics such as production of specific IgE antibodies and TH2 dominance. |
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| 書誌情報 |
中村学園大学薬膳科学研究所研究紀要 en : Proceedings of PAMD Institute of Nakamura Gakuen University 号 1, p. 1-10, 発行日 2008-03-31 |
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| 出版者 | ||||||
| 出版者 | 中村学園大学薬膳科学研究所 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 18829384 | |||||
