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植物成分apigeninの動物肝ミクロゾームによる代謝(自然科学編)
https://nakamura-u.repo.nii.ac.jp/records/954
https://nakamura-u.repo.nii.ac.jp/records/95455fb35da-e98a-4214-a350-f9dcca7b4d37
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00005180688.pdf (648.3 kB)
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| アイテムタイプ | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-14 | |||||
| タイトル | ||||||
| タイトル | 植物成分apigeninの動物肝ミクロゾームによる代謝(自然科学編) | |||||
| タイトル | ||||||
| タイトル | In vitro Metabolism of Apigenin by Liver Microsomes of Rats, Guinea Pigs and Hamsters | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1155311X | |||||
| 著者 |
太田, 千穂
× 太田, 千穂× 松尾, 美樹× 枩岡, 樹子× 太田, 英明× 古賀, 信幸× Ohta, Chiho× Matsuo, Miki× Matsuoka, Mikiko× Ohta, Hideaki× Koga, Nobuyuki |
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| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部 | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Nakamura Gakuen University | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Nakamura Gakuen University | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Nakamura Gakuen University | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Nakamura Gakuen University | |||||
| 著者所属(英) | ||||||
| 言語 | en | |||||
| 値 | Nakamura Gakuen University | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Species and sex differences in the in vitro metabolism of apigenin (5,7,4'-trihydroxyflavone), a flavonoid abundant in plants, were examined using liver microsomes of rats, guinea pigs and hamsters and effect of two cytochrome P450 (P450) inducers, phenobarbital (PB) and 3-methylcholanthrene (MC), on apigenin metabolism was also examined. When incubated with animal liver microsomes and NADPH for 20 min at 37℃, apigenin was mainly oxidized to give a metabolite (M-1) in all species used in this study. M-1 was determined to be 3'-hydroxy-apigenin (luteolin) by a complete agreement of chromatographic behavior in HPLC. In untreated microsomes, the order of the activity to form luteolin was guinea pigs ≫ rats > hamsters. A significant sex difference in luteolin formation was observed in rats and hamsters. Especially, male rat liver microsomes produced luteolin at 6 times faster rate than female ones. PB-treatment did not almost affect the apigenin metabolism, whereas MC-treatment accelerated the metabolism in all species. Immunoinhibition study using antisera against rat CYP1A1 and hamster CYP1A2 revealed an involvement of both P450 enzymes in apigenin metabolism. These results suggest that the 3'-hydroxylation of apigenin to luteolin is catalyzed by MC-inducible P450 enzymes (CYP1A1 and CYP1A2) and a male-specific P450 (CYP2C11). | |||||
| 書誌情報 |
中村学園大学・中村学園大学短期大学部研究紀要 en : Bulletin of Nakamura Gakuen University and Nakamura Gakuen Junior College 巻 40, 発行日 2008-03-01 |
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| 表示順 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 23 | |||||
| アクセション番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KJ00005180688 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13477331 | |||||
