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2,2',3,4',5,5',6-七塩素化ビフェニル(CBl87)の主代謝物の合成
https://nakamura-u.repo.nii.ac.jp/records/883
https://nakamura-u.repo.nii.ac.jp/records/88376cb844e-a772-4076-9ef7-1d7d0301bdac
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004700057.pdf (424.0 kB)
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| アイテムタイプ | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2017-03-14 | |||||
| タイトル | ||||||
| タイトル | 2,2',3,4',5,5',6-七塩素化ビフェニル(CBl87)の主代謝物の合成 | |||||
| タイトル | ||||||
| タイトル | Synthesis of a major metabolite of 2,2',3,4',5,5',6-heptachlorobiphenyl (CB187) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1155311X | |||||
| 著者 |
太田, 千穂
× 太田, 千穂× 原口, 浩一× 尾崎, 真理× 枩岡, 樹子× 古賀, 信幸× Ohta, Chiho× Haraguchi, Koichi× Ozaki, Mari× Matsuoka, Mikiko× Koga, Nobuyuki |
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| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部栄養科学科 | |||||
| 著者所属(日) | ||||||
| 値 | 第一薬科大学健康化学教室 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部栄養科学科 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部栄養科学科 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学栄養科学部栄養科学科 | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Very recently, we have reported 2, 2', 3, 4', 5, 5', 6-heptachlorobiphenyl (heptaCB) (CB187)could be metabolized to two monohydroxy (0H)-metabolites and one dechlorinated OH metabolite by liver microsomes of rats, hamsters and guinea pigs. In this study, in order to determine the metabolic pathways of CB187, we tried to synthesize two OH-PCBs, namely4'-OH-2, 2', 3, 3', 5, 5', 6-heptaCB (CB178) and 3'-OH-CB187. After the diazo-coupling reaction with2, 3, 5, 6-tetrachloroaniline and 2, 3, 6-trichlorophenol as starting materials, the reaction mixture was applied to Silica gel 60 column chromatography. After the elution by n-hexane, the chloroform-eluate was pooled and applied to preparative HPLC. Two peaks containing two OH-PCBs (named as S-1 and S-2) were observed at the retention times of 20.54min and 20.49min in GC. Each fraction was methylated by dimethysulfate and recrystallized in methanol. As a result, the methylated derivative of S-1 and S-2 was obtained with 99.0% and 98.3% in purity and 3.2% (40mg) and 1.7% (21mg) in yield, respectively. From the data in GC/MS and ^1H-NMR, S-1 and S-2 were identified to be 4'-OH-CB178 and 3'-OH-CB187. Finally, a major metabolite of CB187 formed by animal liver microsomes was 4'-OH-CB178, whereas 3'-OH-CB187 was not found in animal. | |||||
| 書誌情報 |
中村学園大学・中村学園大学短期大学部研究紀要 en : Bulletin of Nakamura Gakuen University and Nakamura Gakuen Junior College 巻 38, 発行日 2006-03-15 |
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| 表示順 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 28 | |||||
| アクセション番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KJ00004700057 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13477331 | |||||
