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The effects of magnesium on the intracellular calcium concentrations and constriction in porcine vascular smooth muscle
https://nakamura-u.repo.nii.ac.jp/records/847
https://nakamura-u.repo.nii.ac.jp/records/84703d118b8-7941-44e6-8661-439b372fe589
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00004183410.pdf (643.4 kB)
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| アイテムタイプ | [ELS]紀要論文 / Departmental Bulletin Paper(1) | |||||
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| 公開日 | 2017-03-14 | |||||
| タイトル | ||||||
| タイトル | The effects of magnesium on the intracellular calcium concentrations and constriction in porcine vascular smooth muscle | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 雑誌書誌ID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA1155311X | |||||
| 論文名よみ | ||||||
| タイトル | The effects of magnesium on the intracellular calcium concentrations and constriction in porcine vascular smooth muscle | |||||
| 著者 |
長光, 博史
× 長光, 博史× 阿部, 志麿子× Nagamitsu, Hiroshi× Abe, Shimako |
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| 著者所属(日) | ||||||
| 値 | 中村学園大学短期大学部食物栄養科 | |||||
| 著者所属(日) | ||||||
| 値 | 中村学園大学短期大学部食物栄養科 | |||||
| 抄録(英) | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Recently, much attention has been paid to the physiological effects of magnesium ion (Mg^<2+> ), highly contained in bittern, known as "nigari" among health-conscious people. It is well accepted that the vasodilatory effect of Mg^<2+> is affected by the antagonism of calcium ion (Ca^<2+> ). However, the pre- cise influence of Mg^<2+> on Ca^<2+> regulation remains to be elucidated. To determine the mechanism of Mg^<2+> on the vasodilatory action, the changes in the tension development and intracellular free Ca^<2+> ([Ca^<2+>]_1) after the administration of Mg^<2+> were analyzed under two distinct stimulations including de- polarization by high potassium ion (K^+) and histamine in porcine vascular smooth muscle cells (VSMC). In conclusion, the mechanism by which Mg^<2+> suppresses the tension in VSMC is hypothe- sized to be as follows; 1. It represses the influx of [Ca^<2+>]_1 through channels on the plasma membrane. 2. It has no effect on the intracellular Ca^<2+> release. 3. It leads to a down-regulation of the tension force by reducing [Ca^<2+>]_1 without affecting the sensitivity to Ca2+ in contractile elements. | |||||
| 書誌情報 |
中村学園大学・中村学園大学短期大学部研究紀要 en : Bulletin of Nakamura Gakuen University and Nakamura Gakuen Junior College 巻 37, 発行日 2005-03-15 |
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| 表示順 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 27 | |||||
| アクセション番号 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | KJ00004183410 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13477331 | |||||
